Djordjević V B, Pejović M, Cukuranović R, Lecić N, Stefanović V
Srp Arh Celok Lek. 1994 Jan-Feb;122(1-2):16-8.
Etiology and pathogenesis of endemic nephropathy (EN) are unknown and in this work the possible pathogenetic role of disturbed antioxidant protection, estimated by the activity of erythrocyte catalase, was evaluated. In patients with EN as well as in clinically healthy members of their families a statistically significant increase in catalase activity (16.7 +/- 0.63 x 10(4) U/g Hb) compared to the control group of the blood bank donors from the city of Nish (11.7 +/- 0.69 x 10 U/g Hb) was found. Increased catalase activity, at the level of significance, was also found in clinically healthy members of EN patients families. The increase of catalase activity was considered compensatory to the increased oxydative capacity.
地方性肾病（EN）的病因和发病机制尚不清楚，在本研究中，通过红细胞过氧化氢酶活性评估了抗氧化保护功能紊乱可能的致病作用。与尼什市血库供血者对照组（11.7±0.69 x 10 U/g Hb）相比，发现EN患者及其临床健康的家庭成员的过氧化氢酶活性有统计学意义的升高（16.7±0.63 x 10(4) U/g Hb）。在EN患者家庭的临床健康成员中也发现过氧化氢酶活性有显著升高。过氧化氢酶活性的升高被认为是对氧化能力增加的一种代偿。
