Danesi Giovanni, Zanoletti Elisabetta, Mazzoni Antonio
ENT Department and Microsurgery of the Skull Base, Ospedali Riuniti, Bergamo, Italy.
Skull Base. 2007 May;17(3):173-80. doi: 10.1055/s-2007-977470.
To present our experience of salvage surgery for recurrent nasopharyngeal carcinoma after primary treatment by radiotherapy.
Eleven of 25 patient treated for nasopharyngeal carcinoma between 1990 and 2003 with radiotherapy had either residual or recurrent disease and underwent salvage surgery. The type C infratemporal fossa approach was used to access residual tumor. The patients' progress was followed by clinical examination and interval magnetic resonance scans.
The results were analyzed in terms of morbidity and oncological outcome; patients were recorded as NED (no existing disease), AWD (alive with disease), and DOD (died of disease). A disease-free survival rate of 72% was achieved in the salvage surgery group of patients and an overall disease-free survival rate of 56% applied to the initial cohort of 25 patients, following both the single mode and combined treatment.
Salvage surgery is feasible for patients with recurrent nasopharyngeal carcinoma and may be achieved with minimal morbidity using the type C infratemporal fossa approach.
介绍我们对鼻咽癌患者经放射治疗后复发进行挽救性手术的经验。
1990年至2003年间接受放射治疗的25例鼻咽癌患者中，有11例存在残留或复发病灶并接受了挽救性手术。采用C型颞下窝入路来处理残留肿瘤。通过临床检查和定期磁共振扫描来跟踪患者的病情进展。
从发病率和肿瘤学结局方面分析结果；患者被记录为无疾病生存（NED）、带瘤生存（AWD）和死于疾病（DOD）。挽救性手术组患者的无病生存率达到72%，对于最初的25例患者队列，在采用单一模式和联合治疗后，总体无病生存率为56%。
挽救性手术对于复发性鼻咽癌患者是可行的，并且采用C型颞下窝入路可能以最小的发病率实现该手术。
