Klusoňová P, Zemanová Z
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Physiol Res. 2007;56(5):651-654. doi: 10.33549/physiolres.931314.
Growth of the remnant embryonic kidney (the mesonephros), as expressed by wet weight, was more rapid in the chick embryos with experimentally induced unilateral renal agenesis compared to controls. The difference was significant between embryonic days 8-12, when the doubled weights of remnant kidneys were increased compared with the weights of paired control kidneys. The excessive growth of the mesonephros ceased on day 14, when the normal physiological regression of the embryonic kidney begins. In the definitive kidney, the metanephros, no significant differences in weights of the control vs. remnant metanephros were found on days 10-14. The characteristics of increased mesonephric growth were evaluated by determination of DNA/protein ratios in homogenates of the kidneys. Significant cellular hypertrophy was found in both the mesonephros and metanephros of the embryos with URA on day 10. Additionally, a non-significant cellular hyperplasia was also revealed in the remnant mesonephros on day 8. This gives evidence that the growth stimuli to the mesonephroi were probably strongest between days 8-10 and that they manifested in the remnant mesonephros only.
以湿重表示的残余胚胎肾（中肾）的生长，在实验性诱导单侧肾缺如的鸡胚胎中比对照组更快。在胚胎第8 - 12天，残余肾的重量翻倍，与成对的对照肾重量相比有显著差异。当中肾的过度生长在第14天停止时，胚胎肾开始正常生理退化。在终末肾（后肾）中，在第10 - 14天，对照后肾与残余后肾的重量没有显著差异。通过测定肾匀浆中的DNA/蛋白质比率来评估中肾生长增加的特征。在第10天，单侧肾缺如胚胎的中肾和后肾均发现明显的细胞肥大。此外，在第8天的残余中肾中也发现了不显著的细胞增生。这表明对中肾的生长刺激可能在第8 - 10天最强，并且仅在残余中肾中表现出来。
