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目前的哮喘控制情况能否预测美国黑人学龄前城市儿童未来的医疗保健使用情况?

Does current asthma control predict future health care use among black preschool-aged inner-city children?

作者信息

Sharma Hemant P, Matsui Elizabeth C, Eggleston Peyton A, Hansel Nadia N, Curtin-Brosnan Jean, Diette Gregory B

机构信息

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Pediatrics. 2007 Nov;120(5):e1174-81. doi: 10.1542/peds.2007-0206.

Abstract

OBJECTIVES

Factors predictive of future asthma must be identified among young inner-city children, who suffer disproportionately from asthma. We investigated whether current asthma control predicts future asthma-related health care use among inner-city preschool-aged children with asthma.

METHODS

A total of 150 inner-city preschool-aged children with asthma were followed prospectively for 6 months. At baseline, symptom frequency and reliever-medication use were assessed to classify children into National Asthma Education and Prevention Program-derived control categories. Long-term controller-medication use was also assessed, as well as asthma-related health care use at baseline and at 3 and 6 months.

RESULTS

The mean age was 4.4 years, 92% were black, and 39% reported long-term controller use. At baseline, 37% were classified as having mild-intermittent, 17% had mild-persistent, 21% had moderate-persistent, and 25% had severe-persistent asthma control. Significant changes in asthma control were observed over time, including 46% of children originally categorized with mild-intermittent asthma who had worsened asthma control by 3 months. Asthma control significantly predicted future health care use 3 months later but not 6 months later. Multivariate analyses showed that, once control status was known, reported use of long-term controller medication added little additional predictive value.

CONCLUSIONS

Among inner-city preschool-aged children, significant fluctuations in asthma control occur as early as 3 months after assessment. Poor control but not long-term controller-medication use is an independent predictor of future asthma-related health care use at 3 months but is not significantly predictive of 6-month outcomes. Therefore, clinicians caring for inner-city children with asthma should consider reassessing asthma control at least every 3 months to identify those at highest future risk and to provide early interventions.

摘要

目的

必须在哮喘患病率极高的城市中心区幼儿中确定未来哮喘的预测因素。我们调查了当前的哮喘控制情况是否能预测城市中心区学龄前哮喘儿童未来与哮喘相关的医疗保健使用情况。

方法

对总共150名城市中心区学龄前哮喘儿童进行了为期6个月的前瞻性随访。在基线时,评估症状频率和缓解药物的使用情况,以便将儿童分类为符合国家哮喘教育和预防计划的控制类别。还评估了长期控制药物的使用情况,以及基线时、3个月和6个月时与哮喘相关的医疗保健使用情况。

结果

平均年龄为4.4岁,92%为黑人,39%报告长期使用控制药物。在基线时,37%被分类为轻度间歇性哮喘,17%为轻度持续性哮喘,21%为中度持续性哮喘,25%为重度持续性哮喘控制。随着时间的推移,观察到哮喘控制情况有显著变化,包括最初被分类为轻度间歇性哮喘的儿童中有46%在3个月时哮喘控制情况恶化。哮喘控制情况在3个月后能显著预测未来的医疗保健使用情况,但在6个月后则不能。多变量分析表明,一旦了解了控制状态,报告的长期控制药物使用情况几乎没有额外的预测价值。

结论

在城市中心区学龄前儿童中,哮喘控制情况早在评估后3个月就会出现显著波动。控制不佳而非长期使用控制药物是未来3个月与哮喘相关的医疗保健使用的独立预测因素,但对6个月的结果没有显著预测作用。因此,照顾城市中心区哮喘儿童的临床医生应考虑至少每3个月重新评估一次哮喘控制情况,以确定未来风险最高的儿童,并提供早期干预。

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