Bangstad H J, Try K, Dahl-Jørgensen K, Hanssen K F
Aker Diabetes Research Center, Department of Pediatrics, Medicine and Clinical Chemistry, Aker University Hospital, Oslo, Norway.
Diabetes Care. 1991 Nov;14(11):1094-7. doi: 10.2337/diacare.14.11.1094.
We compared a new semiquantitative dipstick test for microalbuminuria (Micral-Test) with a quantitative immunoturbidimetric method.
This correlation study was performed at a pediatric and medical outpatient clinic at a university hospital. Overnight urine samples containing less than 200 mg/L albumin from 186 diabetic patients were analyzed.
The correlation coefficient between the new semiquantitative method and the immunoturbidimetric reference method was 0.82. Elevated albumin concentration was defined as greater than 20 mg/L albumin in overnight urine, and the prevalence of samples with values above this level was 28%. By this definition, the Micral-Test assay level greater than or equal to 20 mg/L had a sensitivity of 92.3% and a specificity of 82.1%. Of the diabetic subjects, 84.9% were correctly classified as having elevated urinary albumin concentration or not.
The Micral-Test is useful for in-clinic screening for elevated urinary albumin concentration and monitoring the development of urinary albumin excretion in the low microalbuminuric range.
我们将一种新的微量白蛋白尿半定量试纸检测法（Micral-Test）与定量免疫比浊法进行了比较。
这项相关性研究在一家大学医院的儿科和内科门诊进行。对186例糖尿病患者的过夜尿样进行了分析，这些尿样中白蛋白含量低于200mg/L。
新的半定量方法与免疫比浊参考方法之间的相关系数为0.82。过夜尿中白蛋白浓度升高定义为大于20mg/L，该水平以上样本的患病率为28%。根据这一定义，Micral-Test检测水平大于或等于20mg/L时，灵敏度为92.3%，特异性为82.1%。在糖尿病受试者中，84.9%被正确分类为尿白蛋白浓度升高或未升高。
Micral-Test有助于临床筛查尿白蛋白浓度升高，并监测低微量白蛋白尿范围内尿白蛋白排泄的发展情况。
