de Grauw W J, van de Lisdonk E H, van de Hoogen H J, van Gerwen W H, van den Bosch W J, Willems J L, van Weel C
Department of General Practice and Social Medicine, University of Nijmegen, The Netherlands.
Diabet Med. 1995 Aug;12(8):657-63. doi: 10.1111/j.1464-5491.1995.tb00565.x.
To evaluate the Micral test, a semiquantitative dipstick test, in a general practice setting, 317 Type 2 diabetic patients completed a screening for microalbuminuria by means of the Micral test as well as immuno-nephelometry with the Disc 120 immuno-nephelometer (Hyland, Nivelles, Belgium). Data were collected in 10 general practices performing the Nijmegen Monitoring Project. At a regular check-up each Type 2 diabetic patient was asked to collect first morning urine samples on three consecutive days. The sensitivity of the Micral test was 67%, the specificity 93%. Between the practices the sensitivity ranged from 58% to 81%, the specificity from 87% to 95%. Microalbuminuria, defined as a mean urine albumin concentration > or = 20 mg I-1 by nephelometry on three consecutive days, was found in 66 patients (21%). The first Micral test correctly picked out these patients with microalbuminuria in 70% of the cases and in 90% those patients without microalbuminuria. The diagnostic performance of the Micral test was further proved by a Receiver Operating Characteristic (ROC) curve. The Area Under the Curve (AUC) of the Micral test was 0.84 (95% CI 0.78-0.90). Micral test results of 0 and 10 should be regarded as negative.
为了在普通医疗环境中评估半定量试纸条检测Micral试验，317例2型糖尿病患者通过Micral试验以及使用Disc 120免疫比浊仪（比利时尼韦勒海兰公司）的免疫比浊法完成了微量白蛋白尿筛查。数据收集于开展奈梅亨监测项目的10家普通医疗机构。在定期体检时，要求每位2型糖尿病患者连续三天收集晨尿样本。Micral试验的敏感性为67%，特异性为93%。各医疗机构间敏感性范围为58%至81%，特异性范围为87%至95%。通过比浊法测定连续三天平均尿白蛋白浓度≥20mg/L定义为微量白蛋白尿，66例患者（21%）检测出微量白蛋白尿。首次Micral试验在70%的病例中正确检出了这些微量白蛋白尿患者，在90%的无微量白蛋白尿患者中正确做出判断。Micral试验的诊断性能通过受试者工作特征（ROC）曲线得到进一步验证。Micral试验的曲线下面积（AUC）为0.84（95%可信区间0.78 - 0.90）。Micral试验结果为0和10应视为阴性。
