环丙沙星和诺氟沙星对大鼠的致焦虑潜能
Anxiogenic potential of ciprofloxacin and norfloxacin in rats.
作者信息
Sen S, Jaiswal A K, Yanpallewar S, Acharya S B
机构信息
Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
出版信息
Singapore Med J. 2007 Nov;48(11):1028-32.
INTRODUCTION
The possible anxiogenic effects of fluoroquinolones, namely ciprofloxacin and norfloxacin, were investigated in adult Charles Foster albino rats of either sex, weighing 150-200 g.
METHODS
The drugs were given orally, in doses of 50 mg/kg for five consecutive days and the experiments were performed on the fifth day. The tests included open-field exploratory behaviour, elevated plus maze and elevated zero maze, social interaction and novelty-suppressed feeding latency behaviour.
RESULTS
The results indicate that ciprofloxacin- and norfloxacin-treated rats showed anxious behaviour in comparison to control rats in all the parameters studied. However, ciprofloxacin- and norfloxacin-treated rats did not differ significantly from each other in various behavioural parameters.
CONCLUSION
The present experimental findings substantiate the clinically observed anxiogenic potential of ciprofloxacin and norfloxacin.
引言
研究了氟喹诺酮类药物（即环丙沙星和诺氟沙星）对体重150 - 200克的成年雄性和雌性查尔斯·福斯特白化大鼠可能产生的致焦虑作用。
方法
连续五天口服给予药物，剂量为50毫克/千克，并在第五天进行实验。测试包括旷场探索行为、高架十字迷宫和高架零迷宫、社交互动以及新奇抑制摄食潜伏期行为。
结果
结果表明，与对照大鼠相比，接受环丙沙星和诺氟沙星治疗的大鼠在所有研究参数中均表现出焦虑行为。然而，接受环丙沙星和诺氟沙星治疗的大鼠在各种行为参数上彼此之间没有显著差异。
结论
目前的实验结果证实了临床上观察到的环丙沙星和诺氟沙星的致焦虑潜力。
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