Skrabalak Sara E, Au Leslie, Lu Xianmao, Li Xingde, Xia Younan
University of Washington, Department of Chemistry, Seattle, Washington 98195, USA.
Nanomedicine (Lond). 2007 Oct;2(5):657-68. doi: 10.2217/17435889.2.5.657.
Gold nanocages represent a novel class of biocompatible vectors with potential applications in drug delivery, tumor/tissue imaging and photothermal therapy. They are prepared through the galvanic-replacement reaction between Ag nanostructures and HAuCl(4). By controlling the amount of HAuCl(4) added, we can tune the surface-plasmon resonance peaks of the Au nanocages into the near-infrared, where the attenuation of light by blood and soft tissue is relatively low. Here, we highlight recent advances in the synthesis and utilization of Au nanocages for cancer detection and treatment. We have tailored the optical properties of Au nanocages for use as contrast agents in optical coherence tomography and as transducers for the selective photothermal ablation of cancer cells. Our results show improved optical coherence tomography image contrast when Au nanocages are added to tissue phantoms as well as the selective photothermal destruction of breast cancer cells in vitro when immunotargeted Au nanocages are used.
金纳米笼是一类新型的生物相容性载体，在药物递送、肿瘤/组织成像和光热治疗方面具有潜在应用价值。它们是通过银纳米结构与氯金酸（HAuCl₄）之间的置换反应制备而成。通过控制氯金酸的添加量，我们可以将金纳米笼的表面等离子体共振峰调至近红外区域，在该区域血液和软组织对光的衰减相对较低。在此，我们重点介绍金纳米笼在癌症检测与治疗的合成及应用方面的最新进展。我们已对金纳米笼的光学性质进行了调整，使其用作光学相干断层扫描中的造影剂以及用于癌细胞选择性光热消融的换能器。我们的结果表明，当将金纳米笼添加到组织模型中时，光学相干断层扫描图像对比度得到改善，并且当使用免疫靶向金纳米笼时，体外乳腺癌细胞会被选择性光热破坏。
