Ahmad P, Ali S M, Fakhir S, Chandra J
Department of Pediatrics, J.N. Medical College, A.M.U., Aligarh.
Indian Pediatr. 1991 Oct;28(10):1167-70.
Serum and CSF levels of CRP were measured by radial immunoassay in 99 subjects consisting of 20 controls, 34 pyogenic meningitis (PM), 21 tuberculous meningitis (TBM) and 24 viral encephalitis (VE). There was significant difference in the CRP levels (p less than 0.01) depending on the type of disease in both serum and CSF. The initial serum and CSF levels of CRP in patients with TBM was intermediate between those of PM and VE and were found to be significantly (p less than 0.001) low when compared with three days post treatment levels in children with PM. Both serum and CSF-CRP levels were significantly high (p less than 0.001) in patients succumbing to death than those who survived. Measurement of CRP in serum and CSF is a useful parameter in differentiating partially treated PM from TBM.
采用放射免疫分析法测定了99名受试者的血清和脑脊液中CRP水平，这些受试者包括20名对照者、34名化脓性脑膜炎（PM）患者、21名结核性脑膜炎（TBM）患者和24名病毒性脑炎（VE）患者。血清和脑脊液中CRP水平因疾病类型不同而存在显著差异（p<0.01）。TBM患者的初始血清和脑脊液CRP水平介于PM和VE患者之间，与PM患儿治疗三天后的水平相比，显著较低（p<0.001）。死亡患者的血清和脑脊液CRP水平均显著高于存活患者（p<0.001）。测定血清和脑脊液中的CRP是区分部分治疗的PM和TBM的有用参数。
