Sindic C J, Collet-Cassart D, Depré A, Laterre E C, Masson P L
J Neurol Sci. 1984 Mar;63(3):339-44. doi: 10.1016/0022-510x(84)90157-6.
The level of C-reactive protein (CRP) was determined in the cerebrospinal fluid (CSF) by particle counting immunoassay. In non-neurological patients (N = 24), CRP was detectable only in 10 samples at concentrations ranging from 1.5 to 37 micrograms/l. The multiple sclerosis group did not differ from the controls. The highest CRP levels were found in viral and bacterial, including tuberculous, infections of the nervous system, with overlapping results for the various types of infections. However, in serum, the levels of CRP were much higher in pyogenic than in viral meningitis. We compared the CSF CRP/serum CRP ratio to the same ratio for albumin and found a significant correlation between the two ratios in viral, but not in bacterial, infections. These results suggest a local consumption of CRP during bacterial meningitis.
采用颗粒计数免疫分析法测定脑脊液（CSF）中的C反应蛋白（CRP）水平。在非神经科患者（N = 24）中，仅在10份样本中检测到CRP，浓度范围为1.5至37微克/升。多发性硬化症组与对照组无差异。在包括结核感染在内的病毒性和细菌性神经系统感染中发现了最高的CRP水平，不同类型感染的结果有重叠。然而，在血清中，化脓性脑膜炎患者的CRP水平远高于病毒性脑膜炎患者。我们将脑脊液CRP/血清CRP比值与白蛋白的相同比值进行比较，发现在病毒性感染中这两个比值之间存在显著相关性，而在细菌性感染中则不存在。这些结果表明细菌性脑膜炎期间CRP存在局部消耗。
