Hollich Volker, Sonnhammer Erik L L
Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Bioinformatics. 2007 Dec 15;23(24):3382-3. doi: 10.1093/bioinformatics/btm521. Epub 2007 Oct 31.
PfamAlyzer is a Java applet that enables exploration of Pfam domain architectures using a user-friendly graphical interface. It can search the UniProt protein database for a domain pattern. Domain patterns similar to the query are presented graphically by PfamAlyzer either in a ranked list or pinned to the tree of life. Such domain-centric homology search can assist identification of distant homologs with shared domain architecture.
PfamAlyzer has been integrated with the Pfam database and can be accessed at http://pfam.cgb.ki.se/pfamalyzer.
PfamAlyzer是一个Java小程序,它能够使用用户友好的图形界面来探索Pfam结构域架构。它可以在UniProt蛋白质数据库中搜索结构域模式。PfamAlyzer会以图形方式在排序列表中或固定到生命树中呈现与查询相似的结构域模式。这种以结构域为中心的同源性搜索有助于识别具有共享结构域架构的远缘同源物。
PfamAlyzer已与Pfam数据库集成,可通过http://pfam.cgb.ki.se/pfamalyzer访问。