膳食铜和铁对大鼠铅中毒某些毒性作用的保护价值。
Protective value of dietary copper and iron against some toxic effects of lead in rats.
作者信息
Klauder D S, Petering H G
出版信息
Environ Health Perspect. 1975 Dec;12:77-80. doi: 10.1289/ehp.751277.
Abstract
Both dietary iron and copper were inversely related to lead absorption as indicated by erythrocyte and kidney lead levels, dietary iron having the greatest effect. Kidney copper values were depressed when dietary iron was low, a condition which was worsened by lead. Lead tended to lower heart cytochrome c oxidase especially when dietary copper was low, but also when dietary copper and zinc were high. Lead interfered with hematopoiesis when dietary copper and/or iron were low, the effect being expecially severe when both essential nutrients were low. These results show the importance of copper and iron nutriture and metabolism as factors which reduce lead toxicity, and emphasize the necessity of considering nutritional status in evaluating lead toxicity.
摘要
红细胞和肾脏中的铅含量表明，膳食铁和铜均与铅吸收呈负相关，其中膳食铁的影响最大。当膳食铁含量较低时，肾脏铜含量会降低，而铅会使这种情况恶化。铅倾向于降低心脏细胞色素c氧化酶的活性，尤其是在膳食铜含量较低时，不过在膳食铜和锌含量较高时也会出现这种情况。当膳食铜和/或铁含量较低时，铅会干扰造血功能，而当这两种必需营养素都较低时，这种影响尤为严重。这些结果表明，铜和铁的营养状况及代谢作为降低铅毒性的因素具有重要意义，并强调在评估铅毒性时考虑营养状况的必要性。
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