Suzuki T, Yoshida A
J Nutr. 1979 Nov;109(11):1974-8. doi: 10.1093/jn/109.11.1974.
The protective and curative effects of high levels of dietary iron and ascorbic acid on moderately long-term toxicity in rats were examined. In rats fed a diet containing 500 ppm of lead for 56 days, growth retardation, reduction of food consumption, anemia, hypertrophy of the kidney and accumulation of lead in the bone and kidney were observed, however, activities of alkaline phosphatase and GOT in the plasma did not change. Addition of 400 ppm of iron and 1% of ascorbic acid to the lead containing diet prevented the growth depression, reduction of food consumption, anemia and decreased the accumulation of lead in tissues. When these compounds were added to the lead containing diet for 18 days after feeding the lead diet alone for 38 days, almost no curative effects on lead toxicity were observed. In contrast to cadmium toxicity, dietary iron and ascorbic acid have no curative effect on established lead toxicity.
研究了高剂量膳食铁和抗坏血酸对大鼠中度长期毒性的保护和治疗作用。给大鼠喂食含500 ppm铅的饲料56天，观察到生长迟缓、食物摄入量减少、贫血、肾脏肥大以及铅在骨骼和肾脏中的蓄积，然而，血浆中碱性磷酸酶和谷草转氨酶的活性并未改变。在含铅饲料中添加400 ppm的铁和1%的抗坏血酸可防止生长抑制、食物摄入量减少、贫血，并减少组织中铅的蓄积。在单独喂食含铅饲料38天后，再在含铅饲料中添加这些化合物18天，几乎未观察到对铅毒性的治疗效果。与镉毒性不同，膳食铁和抗坏血酸对已形成的铅毒性没有治疗作用。
