Pichoff Sebastien, Lutkenhaus Joe
University of Kansas Medical Center, Microbiology, Molecular Genetics and Immunology, 39th and Rainbow Blvd, Kansas City, KS 66160, United States.
Curr Opin Microbiol. 2007 Dec;10(6):601-5. doi: 10.1016/j.mib.2007.09.005. Epub 2007 Nov 5.
An evolving hypothesis is that bacterial cell shape is determined by cytoskeletal elements that localize peptidoglycan synthetic machineries. In most bacteria FtsZ assembles into the Z ring which recruits the machinery necessary for cytokinesis. Most rod shaped cells require MreB which assembles into cables that run between the poles of the cell and distribute various components of peptidoglycan metabolism along the cell length. Cells with other shapes have additional cytoskeletal elements that either localize synthetic machineries or possibly influence their activity.
一种不断发展的假说认为,细菌的细胞形状是由定位肽聚糖合成机制的细胞骨架成分决定的。在大多数细菌中,FtsZ组装成Z环,该环募集胞质分裂所需的机制。大多数杆状细胞需要MreB,MreB组装成在细胞两极之间延伸的细丝,并沿细胞长度分布肽聚糖代谢的各种成分。具有其他形状的细胞有额外的细胞骨架成分,这些成分要么定位合成机制,要么可能影响其活性。