限制多倍体细胞的增殖。

Limiting the proliferation of polyploid cells.

作者信息

Ganem Neil J, Pellman David

机构信息

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell. 2007 Nov 2;131(3):437-40. doi: 10.1016/j.cell.2007.10.024.

DOI:10.1016/j.cell.2007.10.024

PMID:17981108

Abstract

Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.

摘要

细胞分裂中的许多错误会导致胞质分裂失败并产生四倍体细胞。鉴于四倍体可能会产生有害后果，如遗传不稳定，我们将讨论可能已经进化出的直接或间接阻止这些细胞增殖的机制。