Bunyaratavej Narong
Engineering and Tissue Growth Laboratory (CETGL) Mahidol University, Thailand.
Clin Calcium. 2007 Nov;17(11):1752-60.
Vitamin K(2) has dual actions, stimulates osteoblastic functions, for synthesis of osteocalcin, osteonectin and other matrix bone proteins, in addition, new finding, in stem cell culture found osteoblast producing gene expression of collagen type 1, the other action, vitamin K(2) contains mild antiresorpion by inducing the osteoclastic apoptosis. Our study found that postmenopausal and elderly women have high risk of vitamin K(2) deficiency, comparing to the normal value of young, reproductive females. The efficacy of vitamin K(2) will be fulfill benefit after 6 months of administration, prolong use will enhance of bone quality that prevent fracture.
维生素K(2)具有双重作用，刺激成骨细胞功能，以合成骨钙素、骨粘连蛋白和其他基质骨蛋白，此外，新的发现是，在干细胞培养中发现成骨细胞产生I型胶原蛋白的基因表达，另一个作用是，维生素K(2)通过诱导破骨细胞凋亡具有轻度抗吸收作用。我们的研究发现，与年轻的、处于生育期的女性的正常数值相比，绝经后和老年女性维生素K(2)缺乏的风险较高。维生素K(2)在给药6个月后将发挥有益效果，长期使用将提高骨质，预防骨折。
