Tsugawa Naoko, Okano Toshio
Department of Hygienic Sciences, Kobe Pharmaceutical University.
Clin Calcium. 2010 Sep;20(9):1334-40.
Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. Vitamin K is also an important factor for bone metabolism via gamma-carboxylation of vitamin K-dependent proteins such as osteocalcin, matrix Gla protein, and protein S. Recent studies suggest that there is potential vitamin K insufficiency in bone, even in sufficient vitamin K status for blood coagulation. In the present review, the studies concerning relationship between vitamin K status and fracture are reviewed.
维生素K因其在多种血液凝固因子合成中的作用而广为人知。维生素K也是骨代谢的一个重要因素，它通过对维生素K依赖蛋白（如骨钙素、基质Gla蛋白和蛋白S）进行γ-羧化作用来实现。最近的研究表明，即使在血液凝固方面维生素K状态充足，骨骼中仍可能存在维生素K不足的情况。在本综述中，对有关维生素K状态与骨折之间关系的研究进行了综述。
