Nandakumar Kutty Selva, Holmdahl Rikard
Medical Inflammation Research, Lund University, Sweden.
Methods Mol Med. 2007;136:215-23. doi: 10.1007/978-1-59745-402-5_16.
Rheumatoid arthritis (RA) is a polygenic and multifactorial disease. Many complex immunological and genetic interactions are involved in the final out come of the clinical disease. To understand the various disease pathways operating during the disease course, we need many different animal models. Collagen induced arthritis (CIA) is one of the widely used animal models sharing many pathological and histological similarities with RA and antibodies play an important role in the inflammatory phase of CIA. This chapter describes, in detail, an animal model for arthritis using CII specific monoclonal antibodies, the so-called collagen antibody induced arthritis (CAIA), which shares many characteristics of CIA. CAIA model provides an opportunity to study the inflammatory phase of arthritis without involving the priming phase of the immune response. CAIA can be used for not only studying inflammatory processes in arthritis and screening drug candidates controlling joint inflammatory phase but also as a model for studying common mechanisms involved in many antibody mediated diseases.
类风湿性关节炎（RA）是一种多基因和多因素疾病。许多复杂的免疫和基因相互作用参与了临床疾病的最终结局。为了了解疾病过程中运行的各种疾病途径，我们需要许多不同的动物模型。胶原诱导性关节炎（CIA）是广泛使用的动物模型之一，与RA有许多病理和组织学上的相似之处，并且抗体在CIA的炎症阶段起重要作用。本章详细描述了一种使用CII特异性单克隆抗体的关节炎动物模型，即所谓的胶原抗体诱导性关节炎（CAIA），它具有CIA的许多特征。CAIA模型提供了一个机会来研究关节炎的炎症阶段，而无需涉及免疫反应的启动阶段。CAIA不仅可用于研究关节炎中的炎症过程和筛选控制关节炎症阶段的候选药物，还可作为研究许多抗体介导疾病中共同机制的模型。
