School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China.
Ge Jiu People's Hospital, Yunnan Honghe Prefecture Central Hospital, Gejiu, China.
Front Immunol. 2022 May 25;13:887460. doi: 10.3389/fimmu.2022.887460. eCollection 2022.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic and environmental factors. At present, rodent models are primarily used to study the pathogenesis and treatment of RA. However, the genetic divergences between rodents and humans determine differences in the development of RA, which makes it necessary to explore the establishment of new models. Compared to rodents, non-human primates (NHPs) are much more closely related to humans in terms of the immune system, metabolic conditions, and genetic make-up. NHPs model provides a powerful tool to study the development of RA and potential complications, as well as preclinical studies in drug development. This review provides a brief overview of the RA animal models, emphasizes the replication methods, pros and cons, as well as evaluates the validity of the rodent and NHPs models.
类风湿关节炎（RA）是一种由遗传和环境因素共同影响的慢性炎症性自身免疫性疾病。目前，啮齿动物模型主要用于研究 RA 的发病机制和治疗方法。然而，啮齿动物和人类之间的遗传差异决定了 RA 的发展存在差异，这就需要探索新模型的建立。与啮齿动物相比，非人类灵长类动物（NHPs）在免疫系统、代谢条件和遗传组成方面与人类更为接近。NHP 模型为研究 RA 的发展和潜在并发症以及药物开发的临床前研究提供了有力工具。本文简要概述了 RA 动物模型，强调了复制方法、优缺点，并评估了啮齿动物和 NHP 模型的有效性。
