Rebert C S, Hurd R E, Matteucci M J, De LaPaz R, Enzmann D R
SRI International, Menlo Park, CA 94025.
J Neurosci Methods. 1991 Sep;39(2):109-13. doi: 10.1016/0165-0270(91)90076-c.
Because of great inter-individual variability in the sizes and configurations of monkey brains, consistent intracerebral stereotaxic placements are not possible when a general brain atlas is relied upon to derive placement coordinates. We describe a procedure that allows the determination of brain atlases for individual monkeys using proton magnetic resonance imaging and the translation of image coordinates to stereotaxic coordinates. The latter is accomplished by chronically implanting glass beads filled with copper sulfate into the skull to establish a plane horizontal to the stereotaxic plane and to provide reference points for zeroing stereotaxic carriers during intracerebral implants. The efficacy of this procedure was confirmed experimentally.
由于猴脑的大小和结构存在很大的个体差异，当依靠通用脑图谱来推导放置坐标时，无法实现一致的脑内立体定位放置。我们描述了一种程序，该程序允许使用质子磁共振成像确定个体猴子的脑图谱，并将图像坐标转换为立体定位坐标。后者是通过将填充有硫酸铜的玻璃珠长期植入颅骨来完成的，以建立一个与立体定位平面水平的平面，并为脑内植入期间立体定位载体归零提供参考点。该程序的有效性已通过实验得到证实。
