不止是饱腹感：中枢5-羟色胺信号与葡萄糖稳态
More than satiety: central serotonin signaling and glucose homeostasis.
作者信息
Pissios Pavlos, Maratos-Flier Eleftheria
机构信息
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Metab. 2007 Nov;6(5):345-7. doi: 10.1016/j.cmet.2007.10.009.
Abstract
Serotonergic agents have been used in the past for reduction of appetite and body weight. As reported by Zhou et al. (2007) in this issue of Cell Metabolism, they also have unexpected effects on peripheral glucose homeostasis independent of food intake and body weight.
摘要
血清素能药物过去曾被用于降低食欲和体重。正如周等人（2007年）在本期《细胞代谢》中所报道的，它们对外周葡萄糖稳态也有出人意料的影响，且独立于食物摄入和体重。
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2
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J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743.
3
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Nature. 2007 Sep 13;449(7159):228-32. doi: 10.1038/nature06098. Epub 2007 Aug 29.
4
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.AMPK对于能量稳态调节以及POMC和AgRP神经元的葡萄糖感知至关重要。
J Clin Invest. 2007 Aug;117(8):2325-36. doi: 10.1172/JCI31516.
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