Banfi Giuseppe, Di Gaetano Nicola, Lopez Ramon Simon, Melegati Gianluca
IRCCS Istituto Galeazzi, Milan, Italy.
Lab Hematol. 2007;13(3):103-7. doi: 10.1532/LH96.07012.
Sports anemia is a common risk for athletes. Intravasclar hemolysis is the principal source of an accelerated turnover of erythrocytes in sportsmen. The hemolysis induces some biochemical and hematological modifications; in particular, high concentrations of total and indirect (unconjugated) bilirubin could be reported in professional athletes. We recruited 24 rugby players of the Italian National Team. In these athletes we measured hematological parameters, including mean sphered cell volume (MSCV) by means of Coulter LH 750 (Beckman Coulter, Brea, CA, USA), beside biochemical parameters, including bilirubin and haptoglobin. We observed differences in the athletes' indirect bilirubin between the blood drawing performed before the start of training and competitions and the one performed at the end of the competition season. The bilirubin was increased during competition season from 7% to 329% when compared with the baseline value measured before training and competitions. MSCV, in contrast, decreased from a mean of 88.4 fL to 86 fL. The MSCV decrease in association with an indirect bilirubin increase is a specific sign of erythrocyte destruction, and specific training and competitions schemes and diet or therapy modifications should be decided according to their values. The modifications of MSCV are correlated with those of haptoglobin and hemoglobin, but not with reticulocytosis.
运动性贫血是运动员常见的风险。血管内溶血是运动员红细胞周转加速的主要来源。溶血会引发一些生化和血液学改变；特别是，职业运动员中可能会出现总胆红素和间接（未结合）胆红素浓度升高的情况。我们招募了24名意大利国家队的橄榄球运动员。在这些运动员中，我们测量了血液学参数，包括使用库尔特LH 750（美国贝克曼库尔特公司，加利福尼亚州布雷亚）测量平均球形细胞体积（MSCV），此外还测量了生化参数，包括胆红素和触珠蛋白。我们观察到运动员在训练和比赛开始前采血与比赛赛季结束时采血的间接胆红素存在差异。与训练和比赛前测量的基线值相比，比赛赛季期间胆红素增加了7%至329%。相比之下，MSCV从平均88.4飞升降至86飞升。MSCV降低与间接胆红素升高相关是红细胞破坏的一个特定迹象，应根据其数值确定具体的训练和比赛方案以及饮食或治疗调整。MSCV的变化与触珠蛋白和血红蛋白的变化相关，但与网织红细胞增多无关。
