Kodama Hiroshi
Laboratory of Veterinary Immunology, Course of Veterinary Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Japan.
J Vet Med Sci. 2007 Oct;69(10):1069-71. doi: 10.1292/jvms.69.1069.
Humic substances are formed during the decomposition of organic matter in humus that found in many natural environments in which organic materials and microorganisms have been present. In the present study, humus extract exhibited antitumor effect on L1210 tumor development in isogeneic DBA/2 mice with the delay of tumor formation and a significant smaller tumor mass that infer a significant increase of life span of mice. The antitumor effect was not due to direct killing of L1210 or induction of apoptosis in tumor cells by humus extract.
腐殖质是在腐殖土中有机物分解过程中形成的，腐殖土存在于许多有有机物质和微生物的自然环境中。在本研究中，腐殖质提取物对同基因DBA/2小鼠的L1210肿瘤发展具有抗肿瘤作用，表现为肿瘤形成延迟且肿瘤块显著更小，这意味着小鼠寿命显著延长。这种抗肿瘤作用并非由于腐殖质提取物直接杀死L1210或诱导肿瘤细胞凋亡。
