Nagata Kaori, Kihara Yasuyuki, Eguchi Ryoji, Nakamura Hayato, Yoshikawa Ichiro, Otsuki Makoto
Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 2007 Nov;104(11):1652-7.
A 56-year-old man was admitted to our hospital in July 2000 because of epigastralgia and back pain with past history of repeated upper abdominal pain due to acute pancreatitis since 1995. Abdominal computed tomography on admission showed a swelling in the pancreas head and several large pancreatic pseudocysts. He was diagnosed as acute pancreatitis based on abdominal pain, elevated pancreatic enzymes and computed tomography finding, and given 50 microg octreotide subcutaneously for the treatment of pancreatic pseudocysts. Within 3 hours after octreotide injection, he complained of upper abdominal pain and had an elevated serum amylase level. Abdominal pain disappeared after cessation of octreotide injection and the patient was discharged free from abdominal pain. Octreotide might cause acute pancreatitis by inducing spasm of the sphincter of Oddi. Careful check-up of the patients might be needed during treatment with octreotide.
一名56岁男性于2000年7月因上腹部疼痛和背痛入院，自1995年起有因急性胰腺炎反复出现上腹部疼痛的病史。入院时腹部计算机断层扫描显示胰头肿胀及多个大的胰腺假性囊肿。基于腹痛、胰酶升高及计算机断层扫描结果，他被诊断为急性胰腺炎，并皮下注射50微克奥曲肽以治疗胰腺假性囊肿。奥曲肽注射后3小时内，他诉说上腹部疼痛，血清淀粉酶水平升高。停止注射奥曲肽后腹痛消失，患者出院时无腹痛。奥曲肽可能通过诱发Oddi括约肌痉挛而导致急性胰腺炎。在用奥曲肽治疗期间可能需要对患者进行仔细检查。
