Xu Feng, Chen Yu-Guo, Geng Yong-Jian, Zhang He, Jiang Chun-Xiao, Sun Yi, Li Rui-Jian, Sagar Madi Bidya, Xue Li, Zhang Yun
Department of Emergency, Qilu Hospital of Shandong University, Jinan, China.
Tohoku J Exp Med. 2007 Nov;213(3):215-20. doi: 10.1620/tjem.213.215.
Alcohol consumption has an important effect on coronary atherosclerotic heart disease (CAD). Acetaldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism. A G-to-A missense mutation of ALDH2 gene, which causes a Glu > Lys(504) substitution, was recently shown to be associated with carotid atherosclerosis; however, its relationship with coronary atherosclerosis has not been well studied. We, therefore, investigated this relationship in Han Chinese. There are two ALDH2 alleles (1 and 2) and their combination: 1/1 (GG, typical homozygote), 1/2 (GA, heterozygote) and 2/2 (AA, atypical homozygote) in the population. Successive Han Chinese, including 89 with myocardial infarction (MI) and 142 with unstable angina, were recruited, and underwent coronary angiography and gene sequencing. Coronary atherosclerosis severity was expressed by the number of lesioned coronary arteries (>or=50% diameter stenosis) and Gensini score, calculated based on the luminal narrowing degree and its geographic importance, as assessed by angiography. Based on their ALDH2 genotypes, the 231 patients were divided into wild-type (1/1, n = 145) and mutation groups (1/2 and 2/2, n = 86). There were no significant differences in basic clinical data between the two groups; however, the mutation group had significantly higher rates of diabetes mellitus and MI, and lower prevalence of alcohol consumption than wild-type group. Yet, the two groups were not significantly different in coronary atherosclerosis severity. Multiple regression analysis has shown that the ALDH2 genotype 1/2 or 2/2 is an independent risk factor for MI, but is not associated with coronary atherosclerosis severity in Han Chinese.
饮酒对冠状动脉粥样硬化性心脏病（CAD）有重要影响。乙醛脱氢酶2（ALDH2）是酒精代谢中的关键酶。最近研究表明，ALDH2基因的G到A错义突变导致Glu > Lys（504）替换，与颈动脉粥样硬化有关；然而，其与冠状动脉粥样硬化的关系尚未得到充分研究。因此，我们在汉族人群中研究了这种关系。人群中有两种ALDH2等位基因（1和2）及其组合：1/1（GG，典型纯合子）、1/2（GA，杂合子）和2/2（AA，非典型纯合子）。招募了连续的汉族人群，包括89例心肌梗死（MI）患者和142例不稳定型心绞痛患者，对其进行冠状动脉造影和基因测序。冠状动脉粥样硬化严重程度通过病变冠状动脉数量（直径狭窄≥50%）和Gensini评分来表示，Gensini评分是根据血管造影评估的管腔狭窄程度及其部位重要性计算得出的。根据他们的ALDH2基因型，将231例患者分为野生型（1/1，n = 145）和突变组（1/2和2/2，n = 86）。两组的基本临床数据无显著差异；然而，突变组的糖尿病和心肌梗死发生率显著更高，饮酒患病率低于野生型组。然而，两组在冠状动脉粥样硬化严重程度方面无显著差异。多元回归分析表明，ALDH2基因型1/2或2/2是心肌梗死的独立危险因素，但与汉族人群的冠状动脉粥样硬化严重程度无关。
