Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne). 2024 Mar 19;15:1333595. doi: 10.3389/fendo.2024.1333595. eCollection 2024.
Acetaldehyde dehydrogenase 2 (ALDH2) had reported as a prominent role in the development of cardiometabolic diseases among Asians. Our study aims to investigate the relationship between ALDH2 polymorphism and cardiometabolic risk factors in East Asian population.
We searched databases of PubMed, Web of Science, and Embase updated to Oct 30, 2023. We extracted data of BMI, Hypertension, SBP, DBP, T2DM, FBG, PPG, HbA1c, TG, TC, LDL-C and HDL-C.
In total, 46 studies were finally included in our meta-analysis, containing, 54068 GG and, 36820 GA/AA participants. All outcomes related to blood pressure revealed significant results (hypertension OR=0.83 [0.80, 0.86]; SBP MD=-1.48 [-1.82, -1.14]; DBP MD=-1.09 [-1.58, -0.61]). FBG showed a significant difference (MD=-0.10 [-0.13, -0.07]), and the lipid resulted significantly in some outcomes (TG MD=-0.07 [-0.09, -0.04]; LDL-C MD=-0.04 [-0.05, -0.02]). As for subgroups analysis, we found that in populations without severe cardiac-cerebral vascular diseases (CCVDs), GG demonstrated a significantly higher incidence of T2DM (T2DM OR=0.88 [0.79, 0.97]), while the trend was totally opposite in population with severe CCVDs (T2DM OR=1.29 [1.00, 1.66]) with significant subgroup differences.
Our updated meta-analysis demonstrated that ALDH2 rs671 GG populations had significantly higher levels of BMI, blood pressure, FBG, TG, LDL-C and higher risk of hypertension than GA/AA populations. Besides, to the best of our knowledge, we first report GG had a higher risk of T2DM in population without severe CCVDs, and GA/AA had a higher risk of T2DM in population with severe CCVDs. https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023389242.
乙醛脱氢酶 2（ALDH2）已被报道在亚洲人群中心血管代谢疾病的发展中起重要作用。我们的研究旨在探讨东亚人群中 ALDH2 多态性与心血管代谢危险因素的关系。
我们检索了 PubMed、Web of Science 和 Embase 数据库，检索时间截至 2023 年 10 月 30 日。我们提取了 BMI、高血压、SBP、DBP、T2DM、FBG、PPG、HbA1c、TG、TC、LDL-C 和 HDL-C 的数据。
共有 46 项研究最终纳入我们的荟萃分析，其中包括 54068 名 GG 和 36820 名 GA/AA 参与者。所有与血压相关的结果均显示出显著差异（高血压 OR=0.83 [0.80, 0.86]；SBP MD=-1.48 [-1.82, -1.14]；DBP MD=-1.09 [-1.58, -0.61]）。FBG 显示出显著差异（MD=-0.10 [-0.13, -0.07]），一些脂质结果也显著（TG MD=-0.07 [-0.09, -0.04]；LDL-C MD=-0.04 [-0.05, -0.02]）。亚组分析结果显示，在无严重心脑血管疾病（CCVDs）的人群中，GG 发生 T2DM 的风险显著升高（T2DM OR=0.88 [0.79, 0.97]），而在严重 CCVDs 人群中，趋势完全相反（T2DM OR=1.29 [1.00, 1.66]），具有显著的亚组差异。
我们的更新荟萃分析表明，与 GA/AA 人群相比，ALDH2 rs671 GG 人群的 BMI、血压、FBG、TG、LDL-C 水平更高，高血压的风险更高。此外，据我们所知，我们首次报告 GG 人群在无严重 CCVDs 的人群中患 T2DM 的风险更高，而 GA/AA 人群在有严重 CCVDs 的人群中患 T2DM 的风险更高。https://www.crd.york.ac.uk/PROSPERO，标识符 CRD42023389242。
