Bastarrachea Raul A, Kent Jack W, Rozada Guadalupe, Cole Shelley A, López-Alvarenga Juan C, Aradillas Celia, Brito-Zurita Olga, Cerda-Flores Ricardo M, Ibarra-Costilla Emma, Gallegos Esther, Laviada-Molina Hugo, Hernandez-Escalante Victor, Rosas Juan, Machado Anselmo, Vadillo Felipe, Ramos Manuel, Lazalde Brissia, Santa-Olalla Jesus, MacCluer Jean W, Comuzzie Anthony G
Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA.
Hum Biol. 2007 Feb;79(1):121-9. doi: 10.1353/hub.2007.0021.
Cardiovascular disease (CVD) is a major cause of mortality in the Republic of Mexico, and metabolic syndrome, a complex of CVD risk factors, is increasingly prevalent. To date, however, there have been few studies of the genetic epidemiology of metabolic syndrome in Mexico. As a first step in implementing the GEMM Family Study, a large, multicenter collaborative study, we recruited 375 individuals in 21 extended families, without ascertainment on disease, at 9 medical institutions across Mexico. Participants were measured for anthropometric (stature, weight, waist circumference) and hemodynamic (blood pressure, heart rate) phenotypes; glucose, cholesterol, and triglyceride levels were measured in fasting blood. Variance components-based quantitative genetic analyses were performed using SOLAR. All phenotypes except diastolic blood pressure were significantly heritable. Consistent with the definition of metabolic syndrome, many phenotypes exhibited significant environmental correlation, and significant genetic correlations were found between measures of adiposity and fasting glucose and fasting triglyceride levels. These preliminary data represent the first heritability estimates for many of these phenotypes in the Republic of Mexico and indicate that this study design offers excellent power for future gene discovery relative to metabolic disease.
心血管疾病（CVD）是墨西哥共和国的主要死因，而代谢综合征作为一系列心血管疾病风险因素，其患病率日益增加。然而，迄今为止，墨西哥针对代谢综合征的遗传流行病学研究较少。作为开展一项大型多中心合作研究——GEMM家庭研究的第一步，我们在墨西哥全国9家医疗机构的21个大家庭中招募了375名个体，未对疾病进行确诊。对参与者进行了人体测量学（身高、体重、腰围）和血液动力学（血压、心率）表型的测量；并测量了空腹血液中的葡萄糖、胆固醇和甘油三酯水平。使用SOLAR进行基于方差成分的定量遗传分析。除舒张压外，所有表型均具有显著遗传性。与代谢综合征的定义一致，许多表型表现出显著的环境相关性，并且在肥胖测量指标与空腹血糖和空腹甘油三酯水平之间发现了显著的遗传相关性。这些初步数据代表了墨西哥共和国许多此类表型的首次遗传率估计，并表明相对于代谢性疾病，该研究设计为未来的基因发现提供了强大的能力。
