Reding-Bernal Arturo, Sánchez-Pedraza Valentin, Moreno-Macías Hortensia, Sobrino-Cossio Sergio, Tejero-Barrera María Elizabeth, Burguete-García Ana Isabel, León-Hernández Mireya, Serratos-Canales María Fabiola, Duggirala Ravindranath, López-Alvarenga Juan Carlos
Research Division, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.
Endocrinology Service, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.
PLoS One. 2017 Jun 5;12(6):e0178815. doi: 10.1371/journal.pone.0178815. eCollection 2017.
The aim of this study was to estimate the heritability (h2) and genetic correlation (ρG) between GERD symptoms severity, metabolic syndrome components, and inflammation markers in Mexican families.
Cross-sectional study which included 32 extended families resident in Mexico City. GERD symptoms severity was assessed by the ReQuest in Practice questionnaire. Heritability and genetic correlation were determined using the Sequential Oligogenic Linkage Analysis Routines software.
585 subjects were included, the mean age was 42 (±16.7) years, 57% were women. The heritability of the severity of some GERD symptoms was h2 = 0.27, 0.27, 0.37, and 0.34 (p-value <1.0x10-5) for acidity complaints, lower abdominal complaints, sleep disturbances, and total ReQuest score, respectively. Heritability of metabolic syndrome components ranged from 0.40 for fasting plasma glucose to 0.61 for body mass index and diabetes mellitus. The heritability for fibrinogen and C-reactive protein was 0.64 and 0.38, respectively. Statistically significant genetic correlations were found between acidity complaints and fasting plasma glucose (ρG = 0.40); sleep disturbances and fasting plasma glucose (ρG = 0.36); acidity complaints and diabetes mellitus (ρG = 0.49) and between total ReQuest score and fasting plasma glucose (ρG = 0.43). The rest of metabolic syndrome components did not correlate with GERD symptoms.
Genetic factors substantially explain the phenotypic variance of the severity of some GERD symptoms, metabolic syndrome components and inflammation markers. Observed genetic correlations suggest that these phenotypes share common genes. These findings suggest conducting further investigation, as the determination of a linkage analysis in order to identify regions of susceptibility for developing of GERD and metabolic syndrome.
本研究旨在评估墨西哥家庭中胃食管反流病（GERD）症状严重程度、代谢综合征组分和炎症标志物之间的遗传力（h2）和遗传相关性（ρG）。
横断面研究，纳入居住在墨西哥城的32个大家庭。采用实践中需求问卷评估GERD症状严重程度。使用序列寡基因连锁分析程序软件确定遗传力和遗传相关性。
共纳入585名受试者，平均年龄为42（±16.7）岁，57%为女性。部分GERD症状严重程度的遗传力分别为：胃酸相关症状h2 = 0.27，下腹部症状h2 = 0.27，睡眠障碍h2 = 0.37，总需求问卷评分h2 = 0.34（p值<1.0×10-5）。代谢综合征组分的遗传力范围从空腹血糖的0.40到体重指数和糖尿病的0.61。纤维蛋白原和C反应蛋白的遗传力分别为0.64和0.38。发现胃酸相关症状与空腹血糖之间存在显著的遗传相关性（ρG = 0.40）；睡眠障碍与空腹血糖之间（ρG = 0.36）；胃酸相关症状与糖尿病之间（ρG = 0.49）以及总需求问卷评分与空腹血糖之间（ρG = 0.43）。其余代谢综合征组分与GERD症状无相关性。
遗传因素在很大程度上解释了部分GERD症状严重程度、代谢综合征组分和炎症标志物的表型变异。观察到的遗传相关性表明这些表型共享共同基因。这些发现提示需进一步开展研究，即进行连锁分析以确定GERD和代谢综合征易感性区域。
