Ashmarin I P, Liapina L A, Pastorova V E, Kudriashov B A
Patol Fiziol Eksp Ter. 1991 Jul-Aug(4):3-5.
It is shown that preparations of regulatory peptides (RP): interleukin-1, thymoptin, and the endogenous nonpeptide opioid salsalinol produce a marked depolymerization effect on the fibrin-monomer and display nonenzymatic fibrinolytic activity in relation to unstabilized fibrin. Preparations of regulatory peptides thymalin and diphensin of rabbits intensify fibrin polymerization. A single intravenous infusion of diphensin preparation inhibits nonenzymatic fibrinolysis of blood plasma in vivo and in vitro. Repeated intramuscular injections of the immunoactive preparation thymoptin intensify the fibrinolytic properties of blood plasma in rats.
结果表明，调节肽（RP）制剂：白细胞介素-1、胸腺五肽和内源性非肽类阿片样物质萨沙芦醇对纤维蛋白单体具有显著的解聚作用，并对未稳定的纤维蛋白表现出非酶促纤维蛋白溶解活性。兔胸腺素和地芬辛的调节肽制剂可增强纤维蛋白聚合。单次静脉输注地芬辛制剂可在体内和体外抑制血浆的非酶促纤维蛋白溶解。重复肌肉注射免疫活性制剂胸腺五肽可增强大鼠血浆的纤维蛋白溶解特性。
