Liapina L A, Pastorova V E, Kudriashov B A, Zazhireĭ V D, Sokolova E A, Livshits V A, Ashmarin I P
Izv Akad Nauk SSSR Biol. 1990 May-Jun(3):377-82.
Repeated introduction of thymus polypeptide drug thymoptine (8 times every 24 hours, 1 microgram/kg) led to the increase in total and non-enzymatic fibrinolytic activity of blood plasma and the decrease in fibrinogen concentration. Thymoptine could lyse non-stabilized fibrin and cause depolymerization of aggregates of fibrin monomer in virto. Highest depolymerization activity was observed at thymoptine concentration of 10 micrograms/ml.
重复注射胸腺多肽药物胸腺五肽(每24小时8次,1微克/千克)可导致血浆总纤溶活性和非酶纤溶活性增加,纤维蛋白原浓度降低。胸腺五肽可在体外溶解不稳定纤维蛋白,并使纤维蛋白单体聚集体解聚。在胸腺五肽浓度为10微克/毫升时观察到最高解聚活性。