雌激素调节端粒酶活性在衰老过程中的潜在作用。
Potential roles for estrogen regulation of telomerase activity in aging.
作者信息
Bayne Sharyn, Jones Margaret E E, Li He, Liu Jun-Ping
机构信息
Department of Immunology, Central and Eastern Clinical School, Monash University, Prahan, Victoria 3181, Australia.
出版信息
Ann N Y Acad Sci. 2007 Oct;1114:48-55. doi: 10.1196/annals.1396.023.
Estrogen regulates tissue development, function, and aging by regulating expression of critical genes. Recent studies suggest that estrogen promotes cell proliferation by stimulating telomerase activity, an enzyme that plays a key role in extending cell life span. In some estrogen-responsive tissues, estrogen appears important in regulating telomerase activity in vivo. Further characterization will provide a greater understanding of the link between estrogen, telomerase, and aging.
雌激素通过调节关键基因的表达来调控组织发育、功能及衰老过程。近期研究表明，雌激素可通过刺激端粒酶活性来促进细胞增殖，端粒酶是一种在延长细胞寿命中起关键作用的酶。在一些对雌激素有反应的组织中，雌激素在体内调节端粒酶活性方面似乎很重要。进一步的特性描述将有助于更深入地理解雌激素、端粒酶与衰老之间的联系。
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