A tyrosinase inhibitor, Daedalin A, from mycelial culture of Daedalea dickinsii.
作者信息
Morimura Keiji, Yamazaki Chihiro, Hattori Yasunao, Makabe Hidefumi, Kamo Tsunashi, Hirota Mitsuru
机构信息
Interdisciplinary Graduate School of Science and Technology, Shinshu University, Nagano 399-4598, Japan.
出版信息
Biosci Biotechnol Biochem. 2007 Nov;71(11):2837-40. doi: 10.1271/bbb.70266. Epub 2007 Nov 7.
A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC(50): 194 muM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC(50): 16.9 microM) and superoxide anion scavenging activity (IC(50): 28.5 microM).
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