a Department of Biology , Jahrom Branch, Islamic Azad University , Jahrom , Iran.
b Aura Dynamics , Tromsø , Norway.
J Enzyme Inhib Med Chem. 2019 Dec;34(1):279-309. doi: 10.1080/14756366.2018.1545767.
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
酪氨酸酶是一种多铜酶，广泛分布于不同的生物体中，在黑色素生成和酶促褐变中起着重要作用。因此，其抑制剂在化妆品和医药行业中作为脱色剂，在食品和农业行业中作为防褐变化合物具有吸引力。为此，迄今为止，已经通过不同的筛选方法开发了许多天然、半合成和合成抑制剂。本文综述了过去四十年中从各种来源中发现并在生化上进行了表征的酪氨酸酶抑制剂。
