Park Younghee, Moon Byoung-Ho, Yang Heejung, Lee Youngshim, Lee Eungjung, Lim Yoongho
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul, 143-701, Korea.
Magn Reson Chem. 2007 Dec;45(12):1072-5. doi: 10.1002/mrc.2063.
Diosmetin, 5,7,3'-trihydroxy-4'-methoxyflavone shows chemopreventive, antimutagenic, and antiallergic effects. On the other hand, chrysoeriol, 5,7,4'-trihydroxy-3'-methoxyflavone induced nodABC-lacZ in Rhizobium meliloti. Both of them belong to hydroxymethoxy- flavones. One major difference between diosmetin and chrysoeriol is the substituted position of hydroxyl and methoxyl groups. In order to elucidate the relationships between their structures and activity, one of the first things to be done is the determination of their structures. However, most flavones occur widely in nature, and thus it is difficult to obtain in sufficient amounts from natural sources to identify their structures. Assignments of NMR data of several hydroxymethoxyflavones may help us to identify novel flavonoid compounds isolated from natural sources based on their NMR experiments. Therefore, we report here the complete assignments of 1H and 13C NMR data of 13 hydroxymethoxyflavones.
香叶木素，即5,7,3'-三羟基-4'-甲氧基黄酮，具有化学预防、抗诱变和抗过敏作用。另一方面，白杨素，即5,7,4'-三羟基-3'-甲氧基黄酮，可诱导苜蓿根瘤菌中的nodABC - lacZ。它们都属于羟基甲氧基黄酮。香叶木素和白杨素之间的一个主要区别在于羟基和甲氧基的取代位置。为了阐明它们的结构与活性之间的关系，首先要做的事情之一就是确定它们的结构。然而，大多数黄酮在自然界中广泛存在，因此很难从天然来源获得足够量以鉴定其结构。几种羟基甲氧基黄酮的核磁共振数据归属可能有助于我们根据核磁共振实验鉴定从天然来源分离出的新型黄酮类化合物。因此，我们在此报告13种羟基甲氧基黄酮的1H和13C核磁共振数据的完整归属。
