Zargar A H, Ahmad S, Masoodi S R, Wani A I, Bashir M I, Laway B A, Shah Z A
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, PO Box 1098, GPO Srinagar 190001, Kashmir, India.
Postgrad Med J. 2007 Nov;83(985):713-6. doi: 10.1136/pgmj.2007.059113.
The worldwide prevalence of vitamin D deficiency is reported to be high.
To assess the vitamin D status in apparently healthy adults in Kashmir valley by measuring serum 25-hydroxyvitamin D (25 (OH) D).
92 healthy natives (64 men and 28 non-pregnant/non-lactating women, aged 18-40 years), residing in Kashmir for at least last 5 years and not having any suggestion of systemic disease, were selected for this study. The samples were collected throughout the year in both summer and winter months. Vitamin D deficiency was defined as a serum 25 (OH) D concentration of <50 nmol/l and graded as mild (25-50 nmol/l), moderate (12.5-25 nmol/l) and severe (<12.5 nmol/l).
Body mass index, total energy intake, and other nutritional parameters were comparable among subjects in different groups. Overall 76 (83%) of the subjects studied had vitamin D deficiency--25%, 33%, and 25% had mild, moderate, and severe deficiency, respectively. 49 of the 64 males and all but 1 of the 28 females were vitamin D deficient. The prevalence of vitamin D deficiency ranged from 69.6% in the employed group to 100% in the household group. Vitamin D deficiency was equally prevalent in subjects from rural and urban areas. Serum calcium and phosphorus values were comparable in subjects with and without vitamin D deficiency, while daily intake and urinary excretion of calcium were significantly lower in the former. Vitamin D deficient subjects had a significantly lower mean weekly exposure to sunlight.
In spite of abundant sunlight, healthy individuals in Kashmir valley are vitamin D deficient, particularly women. Serum 25 (OH) D concentrations are significantly related to sun exposure.
据报道，维生素D缺乏在全球范围内普遍存在。
通过测量血清25-羟基维生素D（25(OH)D）来评估克什米尔山谷表面健康成年人的维生素D状况。
本研究选取了92名健康本地人（64名男性和28名非孕非哺乳期女性，年龄在18至40岁之间），他们在克什米尔居住至少5年且无任何全身性疾病迹象。样本在夏季和冬季全年采集。维生素D缺乏定义为血清25(OH)D浓度<50 nmol/l，并分为轻度（25 - 50 nmol/l）、中度（12.5 - 25 nmol/l）和重度（<12.5 nmol/l）。
不同组别的受试者在体重指数、总能量摄入和其他营养参数方面具有可比性。总体而言，76名（83%）研究对象存在维生素D缺乏，其中25%、33%和25%分别为轻度、中度和重度缺乏。64名男性中有49名以及28名女性中除1名外均存在维生素D缺乏。维生素D缺乏的患病率在就业组为69.6%，在家务组为100%。农村和城市地区的受试者中维生素D缺乏情况同样普遍。维生素D缺乏和不缺乏的受试者血清钙和磷值具有可比性，而前者的钙每日摄入量和尿排泄量显著更低。维生素D缺乏的受试者平均每周晒太阳时间显著更短。
尽管阳光充足，但克什米尔山谷的健康个体存在维生素D缺乏，尤其是女性。血清25(OH)D浓度与阳光照射显著相关。
