Friesen Melissa C, Demers Paul A, Spinelli John J, Le Nhu D
Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada.
J Occup Environ Hyg. 2008 Jan;5(1):6-14. doi: 10.1080/15459620701734906.
Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) occurs as a complex mixture that is evaluated using specific components, such as benzo(a)pyrene (BaP) and benzene soluble materials (BSM). Factors that influence the relationship between BaP, BSM, and other PAHs within an aluminum smelter were investigated. Personal samples collected from 1978 to 2001 were used: 576 samples were analyzed for both BaP and BSM; 479 samples were analyzed for BaP and nine other particulate PAHs. Differences in the log-transformed ratios (PAH/BaP, BaP/BSM) due to anode paste composition, pot group, season, and job were examined using linear regression. Pot groups represented differences in technology, process conditions, and building properties. The models' predicted PAH/BaP ratios were multiplied by BaP relative potency factors to estimate the relative toxicity of the mixture. The correlation between BaP and BSM depended on the anode paste source (range 0.1-0.8). In linear regression, 27% of the variability in the log-transformed BaP/BSM ratio was explained by coal tar pitch, work area, and job; no seasonal or pot group differences were observed. Within the potrooms, BaP was very strongly correlated with other PAHs (majority > 0.9). Depending on the PAH, between 23% and 89% of the variability in the log-transformed PAH/BSM was explained by season, coal tar pitch, pot group, and job. The BaP toxic equivalency factors of the mixture varied more across job (2.1-3.5) than across coal tar pitch source (1.8-2.8) or pot group (2.3-2.5). Seasonal and work area differences in the relationship between BaP and other PAHs have not been reported previously. Until these relationships are better understood, BaP seems to be a reasonable, albeit imperfect, indicator due to the strong correlation between BaP and other PAHs for a given set of conditions and due to the relative abundance of BaP exposure measurements.
职业性和环境性多环芳烃（PAHs）暴露以复杂混合物的形式存在，可使用特定成分进行评估，如苯并(a)芘（BaP）和苯溶性物质（BSM）。本研究调查了影响铝冶炼厂内BaP、BSM和其他PAHs之间关系的因素。使用了1978年至2001年期间收集的个人样本：576个样本同时分析了BaP和BSM；479个样本分析了BaP和其他9种颗粒状PAHs。使用线性回归分析了由于阳极糊成分、电解槽组、季节和工作岗位导致的对数转换比值（PAH/BaP、BaP/BSM）差异。电解槽组代表了技术、工艺条件和厂房特性的差异。模型预测的PAH/BaP比值乘以BaP相对毒性因子，以估计混合物的相对毒性。BaP与BSM之间的相关性取决于阳极糊来源（范围为0.1 - 0.8）。在线性回归中，煤焦油沥青、工作区域和工作岗位解释了对数转换后的BaP/BSM比值中27%的变异性；未观察到季节或电解槽组差异。在电解车间内，BaP与其他PAHs高度相关（大多数>0.9）。根据PAH的不同，季节、煤焦油沥青、电解槽组和工作岗位解释了对数转换后的PAH/BSM中23%至89%的变异性。混合物的BaP毒性当量因子在不同工作岗位间的变化（2.1 - 3.5）大于在不同煤焦油沥青来源间的变化（1.8 - 2.8）或电解槽组间的变化（2.3 - 2.5）。此前尚未报道过BaP与其他PAHs之间关系的季节性和工作区域差异。在更好地理解这些关系之前，由于在给定条件下BaP与其他PAHs之间存在强相关性，且BaP暴露测量相对丰富，BaP似乎是一个合理的指标，尽管并不完美。
