Smith Roger, Van Helden Dirk, Hirst Jon, Zakar Tamas, Read Mark, Chan Eng-Cheng, Palliser Hannah, Grammatopoulos Dimitris, Nicholson Richard, Parkington Helena C
Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, and School of Biomedical Sciences, University of Newcastle, New South Wales, Australia.
Aust N Z J Obstet Gynaecol. 2007 Dec;47(6):430-7. doi: 10.1111/j.1479-828X.2007.00775.x.
The physiological processes that regulate the onset of parturition and birth are slowly being elucidated, and the points at which pathology can intervene are becoming more apparent. The data support the view that multiple pathways lead to myometrial activation. The clinical corollary is that combinations of tocolytics that operate via different mechanisms may be more effective than single agents. It may also be necessary to divide preterm labour into groups based on underlying mechanisms and to tailor therapy accordingly.
调节分娩发动和出生的生理过程正逐渐被阐明，病理因素可能干预的关键点也越来越明显。数据支持多种途径导致子宫肌层激活的观点。临床推断是，通过不同机制起作用的宫缩抑制剂联合使用可能比单一药物更有效。也可能有必要根据潜在机制将早产分为不同组，并相应地调整治疗方案。
