Bishop Martin J, Gavaghan David J, Trayanova Natalia A, Rodriguez Blanca
Computational Biology Group, University of Oxford Computing Laboratory, Oxford, UK.
J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S75-80. doi: 10.1016/j.jelectrocard.2007.06.020.
Optical mapping is a widely used experimental tool providing high-resolution recordings of cardiac electrical activity. However, the technique is limited by signal distortion due to photon scattering in the tissue. Computational models of the fluorescence recording are capable of assessing these distortion effects, providing important insight to assist experimental data interpretation.
We present results from a new panoramic optical mapping model, which is used to assess distortion in ventricular optical mapping signals during pacing and arrhythmogenesis arising from 3-dimensional photon scattering.
RESULTS/CONCLUSIONS: We demonstrate that accurate consideration of wavefront propagation within the complex ventricular structure, along with accurate representation of photon scattering in 3 dimensions, is essential to faithfully assess distortion effects arising during optical mapping. In this article, examined effects include (1) the specific morphology of the optical action potential upstroke during pacing and (2) the shift in the location of epicardial phase singularities obtained from fluorescent maps.
光学映射是一种广泛使用的实验工具，可提供心脏电活动的高分辨率记录。然而，该技术受到组织中光子散射导致的信号失真的限制。荧光记录的计算模型能够评估这些失真效应，为辅助实验数据解释提供重要见解。
我们展示了一种新的全景光学映射模型的结果，该模型用于评估起搏和心律失常发生过程中由于三维光子散射引起的心室光学映射信号的失真。
结果/结论：我们证明，在复杂的心室结构中准确考虑波前传播，以及在三维中准确表示光子散射，对于如实地评估光学映射过程中产生的失真效应至关重要。在本文中，研究的效应包括：（1）起搏期间光学动作电位上升支的特定形态，以及（2）从荧光图获得的心外膜相位奇点位置的偏移。
