Arevalo Hermenegild J, Boyle Patrick M, Trayanova Natalia A
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Simula Research Laboratory, Oslo, Norway.
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Prog Biophys Mol Biol. 2016 Jul;121(2):185-94. doi: 10.1016/j.pbiomolbio.2016.06.004. Epub 2016 Jun 19.
Current understanding of cardiac electrophysiology has been greatly aided by computational work performed using rabbit ventricular models. This article reviews the contributions of multiscale models of rabbit ventricles in understanding cardiac arrhythmia mechanisms. This review will provide an overview of multiscale modeling of the rabbit ventricles. It will then highlight works that provide insights into the role of the conduction system, complex geometric structures, and heterogeneous cellular electrophysiology in diseased and healthy rabbit hearts to the initiation and maintenance of ventricular arrhythmia. Finally, it will provide an overview on the contributions of rabbit ventricular modeling on understanding the mechanisms underlying shock-induced defibrillation.
目前对心脏电生理学的理解在很大程度上得益于使用兔心室模型进行的计算工作。本文回顾了兔心室多尺度模型在理解心律失常机制方面的贡献。这篇综述将概述兔心室的多尺度建模。然后将重点介绍一些研究成果，这些成果深入探讨了传导系统、复杂几何结构和异质性细胞电生理学在患病和健康兔心脏中对室性心律失常的起始和维持所起的作用。最后，将概述兔心室建模在理解电击除颤潜在机制方面的贡献。
