Ozawa T, Hanaki A, Onodera K
Division of Chemical Pharmacology, National Institute of Radiological Sciences, Chiba-shi, Japan.
Biochem Int. 1991 Jul;24(4):661-7.
The reaction of CuII (edta) (edta: ethylenediaminetetraacetic acid) with hydrogen peroxide (H2O2) was studied in the pH range of 6.0 to 8.0. CuII (edta) did not react with H2O2 in the all pH range examined in the absence of biological reductants. CuII (edta), however, could react with H2O2 in the presence of biological reductants such as ascorbic acid, cysteine and NADH to give thibarbituric acid (TBA) reactive substance, regardless of the pH. From these results, it is concluded that CuII (edta) cannot be bound to H2O2 and that the change of the redox potential of Cu2+ ion on ligating with edta may cause CuII (edta) to be unable to oxidize H2O2.
在pH值为6.0至8.0的范围内研究了CuII（乙二胺四乙酸）（乙二胺四乙酸：乙二胺四乙酸）与过氧化氢（H2O2）的反应。在没有生物还原剂的情况下，在所研究的所有pH范围内，CuII（乙二胺四乙酸）都不与H2O2反应。然而，在存在生物还原剂如抗坏血酸、半胱氨酸和NADH的情况下，CuII（乙二胺四乙酸）可以与H2O2反应生成硫代巴比妥酸（TBA）反应性物质，而与pH无关。从这些结果可以得出结论，CuII（乙二胺四乙酸）不能与H2O2结合，并且Cu2+离子与乙二胺四乙酸配位时氧化还原电位的变化可能导致CuII（乙二胺四乙酸）无法氧化H2O2。
