Berthon G
INSERM U305, Equipe Bioréactifs, Spéciation et Biodisponibilité, Toulouse, France.
Agents Actions. 1993 Jul;39(3-4):210-7. doi: 10.1007/BF01998975.
The anti-inflammatory role of copper is well-known although still largely unexplained. On the other hand, the capacity of copper to induce the formation of damaging .OH radicals in vivo is no longer debated. These two aspects of the physiological activity of copper have been considered to be paradoxical. Arguments developed here show that they may actually derive from a single chemical process, the type of physiological effect observed depending on the ligand bound to the copper ions involved in Fenton chemistry. Both iron and copper are Fenton catalysts. Given its intrinsic coordination properties, however, copper induces more site-specific .OH damage to the ligands bound to it. It, therefore, appears that copper complexes with specific .OH-inactivating ligands (OILs) can be used as "lures" for the Fenton reaction, .OH radicals preferentially formed on these being immediately inactivated. The hypothesis is thus put forward here that copper-OIL complexes acting as effective Fenton catalysts are potential "catalase-like" anti-inflammatory drugs.
铜的抗炎作用众所周知，尽管在很大程度上仍未得到解释。另一方面，铜在体内诱导形成具有损伤性的·OH自由基的能力已不再有争议。铜生理活性的这两个方面被认为是自相矛盾的。这里提出的观点表明，它们实际上可能源于单一的化学过程，观察到的生理效应类型取决于与芬顿化学中涉及的铜离子结合的配体。铁和铜都是芬顿催化剂。然而，鉴于其固有的配位特性，铜对与其结合的配体造成的·OH损伤更具位点特异性。因此，似乎与特定的·OH失活配体（OILs）形成的铜络合物可作为芬顿反应的“诱饵”，在其上优先形成的·OH自由基会立即失活。因此，这里提出的假设是，作为有效的芬顿催化剂的铜 - OIL络合物是潜在的“类过氧化氢酶”抗炎药物。
