Espert Lucile, Codogno Patrice, Biard-Piechaczyk Martine
CPBS, UM1 UM2 CNRS, Institut de Biologie, Montpellier, France.
Autophagy. 2008 Apr;4(3):273-5. doi: 10.4161/auto.5211. Epub 2007 Oct 29.
HIV-1 infection is characterized by a progressive CD4 T cell depletion. It is now accepted that apoptosis of uninfected bystander CD4 T lymphocytes plays a major role in AIDS development. Viral envelope glycoproteins (Env) are mainly involved in inducing this cell death process, but the mechanisms triggered by HIV-1 leading to immunodeficiency are still poorly understood. Recently, we have demonstrated that autophagy is a prerequisite for Env-mediated apoptosis in uninfected CD4 T cells, underlining its role in HIV-1 infection. However, occurrence of autophagy in HIV-1-infected cells has not yet been described. Several hypotheses are discussed, based on the comparison with data from other viral infections.
HIV-1感染的特征是CD4 T细胞逐渐耗竭。目前人们认为，未感染的旁观者CD4 T淋巴细胞凋亡在艾滋病发展过程中起主要作用。病毒包膜糖蛋白（Env）主要参与诱导这一细胞死亡过程，但HIV-1导致免疫缺陷的触发机制仍知之甚少。最近，我们已经证明自噬是Env介导的未感染CD4 T细胞凋亡的先决条件，突显了其在HIV-1感染中的作用。然而，尚未有人描述HIV-1感染细胞中自噬的发生情况。基于与其他病毒感染数据的比较，讨论了几种假说。
