Levine Joseph, Timinsky Igor, Vishne Tali, Dwolatzky Tzvi, Roitman Susana, Kaplan Zeev, Kotler Moshe, Sela Ben-Ami, Spivak Baruch
Department of Psychiatry, Ben Gurion University of the Negev, Beersheva, Israel.
Depress Anxiety. 2008;25(11):E154-7. doi: 10.1002/da.20400.
It has been suggested that an elevated serum or plasma homocysteine level may be a risk factor for neuropsychiatric conditions such as Alzheimer's disease, schizophrenia, and depression. Because depression is closely related to anxiety disorders, and because it has been suggested that stress may be associated with an elevated homocysteine level, we studied whether serum homocysteine levels are elevated in patients with posttraumatic stress disorder (PTSD). Total serum homocysteine levels in 28 male patients with PTSD were compared to those of 223 healthy controls. The effect of PTSD on the serum homocysteine level was significant (F=42.96, P<.0001). In a regression model for the PTSD patients, the duration of PTSD was found to predict serum homocysteine levels (t=2.228, P=.035). Our results suggest that elevated levels of homocysteine in male patients with PTSD may be related to pathophysiological aspects associated with the chronicity of this disorder.
有人提出，血清或血浆同型半胱氨酸水平升高可能是神经精神疾病的一个危险因素，如阿尔茨海默病、精神分裂症和抑郁症。由于抑郁症与焦虑症密切相关，且有人提出压力可能与同型半胱氨酸水平升高有关，我们研究了创伤后应激障碍（PTSD）患者的血清同型半胱氨酸水平是否升高。将28名男性PTSD患者的血清总同型半胱氨酸水平与223名健康对照者的水平进行比较。PTSD对血清同型半胱氨酸水平的影响显著（F = 42.96，P <.0001）。在PTSD患者的回归模型中，发现PTSD的病程可预测血清同型半胱氨酸水平（t = 2.228，P =.035）。我们的结果表明，男性PTSD患者同型半胱氨酸水平升高可能与该疾病慢性化相关的病理生理方面有关。
