Fei YuLang, Wu Kun, Liu Liang
Medical College, Xijing University, Xi'an, China.
School of Materials Science and Engineering, Jiangsu University, Zhenjiang, China.
Front Chem. 2022 Mar 21;10:859963. doi: 10.3389/fchem.2022.859963. eCollection 2022.
The present work was devoted to developing rhodamine-like chemosensing systems for cysteine (Cys) optical recognition. Aiming at low background light and minimal photobleaching effect, up-converting nanocrystals were firstly synthesized and latterly coated by α-cyclodextrin, and finally used as an exciting host. An energy transfer procedure from these nanocrystals and rhodamine sensors was established their spectroscopic analysis and emissive decay dynamics comparison. The binding dynamics of our chemosensors for Cys were revealed to have uncomplicated recognition with a stoichiometric ratio of 1 1. The addition of cysteine increased the emission intensity of the chemosensors. As a consequence, the luminescence off-on effect with sensing selectivity and linear sensing behavior for Cys was demonstrated. Sulfur modification on our chemosensors was shown to be effective in improving their selectivity and photostability.
本研究致力于开发用于半胱氨酸（Cys）光学识别的罗丹明类化学传感系统。为了实现低背景光和最小光漂白效应，首先合成了上转换纳米晶体，随后用α-环糊精进行包覆，最终将其用作激发主体。通过光谱分析和发射衰减动力学比较，建立了这些纳米晶体与罗丹明传感器之间的能量转移过程。结果表明，我们的化学传感器对Cys的结合动力学具有简单的识别过程，化学计量比为1∶1。半胱氨酸的加入增加了化学传感器的发射强度。因此，证明了该化学传感器对Cys具有传感选择性和线性传感行为的发光开-关效应。研究表明，对我们的化学传感器进行硫修饰可有效提高其选择性和光稳定性。
