Santiard-Baron Dominique, Aupetit Joelle, Janel Nathalie
Central Nervous System Department, Aventis, France.
Neurosci Res. 2005 Dec;53(4):447-9. doi: 10.1016/j.neures.2005.09.001. Epub 2005 Oct 6.
Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, total plasma homocysteine levels were evaluated in transgenic mouse models that exhibit abnormalities in their brains that are similar to Alzheimer's patients. No significant difference was observed in blood of murine models compared to control mice, indicating that elevated plasma homocysteine level seems to be a risk marker at the most.
阿尔茨海默病（AD）患者的血浆同型半胱氨酸水平往往会升高。然而，尚不清楚同型半胱氨酸水平异常是阿尔茨海默病的主要病因还是疾病标志物。为了研究阿尔茨海默病对血浆同型半胱氨酸水平的相对影响，在大脑表现出与阿尔茨海默病患者相似异常的转基因小鼠模型中评估了血浆总同型半胱氨酸水平。与对照小鼠相比，在小鼠模型的血液中未观察到显著差异，这表明血浆同型半胱氨酸水平升高充其量似乎是一种风险标志物。
