新型布朗斯特酸催化吲哚与N-苯基硒代邻苯二甲酰亚胺和苯乙烯的三组分烷基化反应。
Novel Brønsted acid catalyzed three-component alkylations of indoles with N-phenylselenophthalimide and styrenes.
作者信息
Zhao Xiaodan, Yu Zhengkun, Xu Tongyu, Wu Ping, Yu Haifeng
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian, Liaoning 116023, PR China.
出版信息
Org Lett. 2007 Dec 6;9(25):5263-6. doi: 10.1021/ol7024795. Epub 2007 Nov 10.
PMID:17994757
Abstract
Novel and efficient Brønsted acid (p-TsOH) catalyzed inter- and intramolecular Friedel-Crafts alkylations have been developed to synthesize selenated three-component coupling and selenation-cyclization indole derivatives. Chemical removal of the phenylseleno moiety was investigated, and the reaction mechanisms were discussed.
摘要
已开发出新型高效的布朗斯特酸（对甲苯磺酸）催化的分子间和分子内傅克烷基化反应，用于合成硒化的三组分偶联产物和硒化环化吲哚衍生物。研究了苯基硒基部分的化学去除方法，并探讨了反应机理。
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