Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, China.
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, School of Pharmaceutical Science of Gannan Medical University, Ganzhou 341000, China.
Molecules. 2022 Jan 25;27(3):772. doi: 10.3390/molecules27030772.
An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an easy-to-handle oxidant, and gram-scalable synthesis. This simple protocol allows one to access a wide range of 3-arylthioindoles, 3-arylselenylindoles, and even 3-thiocyanatoindoles with good to excellent yields.
采用氧化石墨烯作为促进剂，在室温下利用可见光照射，实现了一种高效、通用的 3-硫代吲哚和 3-硒代吲哚的合成方法。该反应具有产率高、操作简单、无需金属和碘、使用易于处理的氧化剂以及可规模化合成等特点。该简便的方法可用于合成各种 3-芳基硫代吲哚、3-芳基硒代吲哚，甚至 3-硫氰酸吲哚，产率良好至优秀。
