Zysk Adam M, Nguyen Freddy T, Oldenburg Amy L, Marks Daniel L, Boppart Stephen A
University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801, USA.
J Biomed Opt. 2007 Sep-Oct;12(5):051403. doi: 10.1117/1.2793736.
Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging and followed a unique path to commercialization for clinical use. Concurrently, significant technological advances were brought about from within the research community, including improved laser sources, beam delivery instruments, and detection schemes. While many of these technologies improved retinal imaging, they also allowed for the application of OCT to many new clinical areas. As a result, OCT has been clinically demonstrated in a diverse set of medical and surgical specialties, including gastroenterology, dermatology, cardiology, and oncology, among others. The lessons learned in the clinic are currently spurring a new set of advances in the laboratory that will again expand the clinical use of OCT by adding molecular sensitivity, improving image quality, and increasing acquisition speeds. This continuous cycle of laboratory development and clinical application has allowed the OCT technology to grow at a rapid rate and represents a unique model for the translation of biomedical optics to the patient bedside. This work presents a brief history of OCT development, reviews current clinical applications, discusses some clinical translation challenges, and reviews laboratory developments poised for future clinical application.
自问世以来，光学相干断层扫描（OCT）技术已从实验室走向临床，又回归实验室。OCT起源于低相干干涉测量以及光学时域和频域反射测量领域，最初用于视网膜成像，并沿着一条独特的商业化道路进入临床应用。与此同时，研究界取得了重大技术进步，包括改进激光源、光束传输仪器和检测方案。虽然其中许多技术改善了视网膜成像，但也使得OCT能够应用于许多新的临床领域。因此，OCT已在包括胃肠病学、皮肤病学、心脏病学和肿瘤学等在内的多种医学和外科专业中得到临床验证。目前，在临床中吸取的经验教训正在推动实验室的一系列新进展，这些进展将通过增加分子敏感性、提高图像质量和加快采集速度再次扩大OCT的临床应用。实验室开发与临床应用的这种持续循环使OCT技术得以快速发展，代表了生物医学光学向患者床边转化的独特模式。本文介绍了OCT发展的简史，回顾了当前的临床应用，讨论了一些临床转化挑战，并综述了有望用于未来临床应用的实验室进展。
