Inagaki O, Fujita Y
Department of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan.
Magnes Res. 1991 Sep-Dec;4(3-4):191-5.
The long term effects of Mg on serum lipids were examined in uraemic rats. Experimental rats were randomized into two groups. Twenty four rats were made uraemic by 5/6 nephrectomy, and another 24 control rats were sham-operated. Both groups were then randomized into three subgroups. These three subgroups of uraemic and control rats received three different diets: a Mg-deficient diet, a moderately Mg-supplemented diet, and a highly Mg-supplemented diet. After 12 weeks on this regimen, all animals were killed. In uraemic rats, serum triglyceride and total cholesterol levels were higher than in control rats. These lipid levels were further increased in uraemic rats on Mg-deficient diet and were decreased in uraemic rats on highly Mg-supplemented diet. These results suggest that disturbance of lipid metabolism in uraemic rats is promoted by low Mg intake and is ameliorated by high Mg intake.
研究了镁对尿毒症大鼠血脂的长期影响。将实验大鼠随机分为两组。24只大鼠通过5/6肾切除术制成尿毒症模型，另外24只对照大鼠进行假手术。然后将两组大鼠再随机分为三个亚组。这三个亚组的尿毒症大鼠和对照大鼠分别接受三种不同的饮食：低镁饮食、适度补镁饮食和高镁饮食。按照此方案喂养12周后，处死所有动物。尿毒症大鼠的血清甘油三酯和总胆固醇水平高于对照大鼠。低镁饮食的尿毒症大鼠这些血脂水平进一步升高，而高镁饮食的尿毒症大鼠血脂水平降低。这些结果表明，低镁摄入会促进尿毒症大鼠脂质代谢紊乱，而高镁摄入可改善这种紊乱。
