Bray Joshua M, Petrone Carl, Filiaggi Mark, Beyea Steven D
Neuroimaging Research Laboratory, National Research Council of Canada, Halifax, Nova Scotia, Canada B3H 3A7.
Solid State Nucl Magn Reson. 2007 Dec;32(4):118-28. doi: 10.1016/j.ssnmr.2007.10.003. Epub 2007 Oct 12.
A MR microscopy experiment is developed and used to characterize fluid ingress and microstructural transformation in degradable calcium polyphosphate (CPP) bioceramics. High-resolution (49microm) maps of fluid density and spin-lattice relaxation rate were obtained as a function of time for CPP immersed in phosphate buffered saline. These results demonstrate clear differences in fluid transport rates and solid matrix microstructure in two differing CPP formulations. CPP has been proposed as a potential implantable device for the delivery of pharmaceuticals, and the magnetic resonance imaging (MRI) data are used in conjunction with previously reported bulk elution results to develop a hypothesis explaining microstructural evolution in these materials. This type of non-destructive evaluation of the structure-transport of fluids in CPP is important to improved design of these functionalized biomaterials for long-term, localized delivery of sustained levels of therapeutic agents.
开展了一项磁共振显微镜实验，用于表征可降解聚磷酸钙（CPP）生物陶瓷中的流体渗入和微观结构转变。将CPP浸入磷酸盐缓冲盐水中，随时间获取了流体密度和自旋晶格弛豫率的高分辨率（49微米）图谱。这些结果表明，两种不同CPP配方在流体传输速率和固体基质微观结构上存在明显差异。CPP已被提议作为一种潜在的药物输送植入装置，磁共振成像（MRI）数据与先前报道的整体洗脱结果结合使用，以建立一个解释这些材料微观结构演变的假设。这种对CPP中流体结构传输的无损评估，对于改进这些功能化生物材料的设计以长期、局部递送持续水平的治疗剂具有重要意义。
